North Virginia Street will be closed between Golden Valley Road and Security Circle on Saturday from 7 a.m. to 7 p.m.
Union Pacific will be replacing a rail crossing in the area.
During the closure, there will be no through traffic between Panther Drive and Golden Valley Road. Local access to the Raliegh Heights area will be allowed during the 12-hour closure.
The City of Reno says the work schedule is subject to change and driver are encouraged to plan ahead and use alternate routes including U.S. 395 and Parr Boulevard.
