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In the nearly seven months since the San Francisco 49ers last played a game that counted, they watched the Seattle Seahawks celebrate a Super Bowl win in the Niners’ home locker room and the Los Angeles Rams get all the hype after an offseason that featured the addition of Myles Garrett. While San Francisco’s NFC West rivals may have gotten lots of the hype, the Niners showed in the season opener that they might also belong on the short list of Super Bowl contenders after beating the Rams 27-7 in the season opener in Australia.

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San Francisco 49ers quarterback Brock Purdy passes under pressure from Los Angeles Rams linebacker Nate Landman during the first half of an NFL football game Friday, Sept. 11, 2026, in Melbourne, Australia. (AP Photo/Asanka Brendon Ratnayake)

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San Francisco 49ers quarterback Brock Purdy celebrates after a runs against the Los Angeles Rams during the second half of an NFL football game, Friday, Sept. 11, 2026, in Melbourne, Australia. (AP Photo/Asanka Brendon Ratnayake)

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Fans watch during the second half of an NFL football game between the Los Angeles Rams and the San Francisco 49ers, Friday, Sept. 11, 2026, in Melbourne, Australia. (AP Photo/Scott Barbour)

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Sam Darnold played just five snaps. A.J. Brown will be sidelined for a while. De’Zhaun Stribling was carted off the field. High-profile injuries are adding up just two games into the NFL season. It’s not even Sunday yet. Darnold got good news about his hip injury. Not so much for Brown. Stribling’s status wasn’t immediately known. NFL teams have to deal with injuries every week. It’s part of football. The teams with the most depth and best backups find ways to overcome key losses. The Seahawks and Patriots have to figure it out quickly.

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Myles Garrett finally acknowledged his knee injury is more serious than he had been letting on following his quiet debut for the Los Angeles Rams in their season-opening defeat in Australia. The reigning AP NFL Defensive Player of the Year made zero tackles and no impact on the game during the Rams’ 27-7 loss to the San Francisco 49ers. Garrett missed much of training camp and the Rams’ recent weeks of practices to rest his knee, but the injury wasn't known to be as serious as Garrett finally acknowledged it is. Garrett's ineffectiveness was just one problem for the Rams' overmatched defense.

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Mike Evans, Demarcus Robinson and Deebo Samuel caught touchdown passes from Brock Purdy, and the San Francisco 49ers routed the Los Angeles Rams 27-7 in the first NFL regular-season game in Australia. Purdy passed for 205 yards against the Rams’ ineffective defense at the Melbourne Cricket Ground in front of 100,021 fans. That's the seventh-largest regular season crowd in NFL history. The San Francisco defense frustrated NFL MVP Matthew Stafford into a 15-for-25 performance for just 155 yards. Kyren Williams scored the NFL’s first Australian touchdown on a 5-yard rush to begin the second quarter. but the Rams’ offense struggled from there.